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HomeMy WebLinkAbout032724 - Study digs into what's driving early-onset colon cancerALERT: BE CAUTIOUS This email originated outside the organization. Do not open attachments or click on links if you are not expecting them. Colorectal cancers in people under age 50 | Expert answer on lymphedema | Colorectal cancer blood test ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ View as Web page <https://secure.fredhutch.org/site/R?i=gOyAQeNWhzFEbmst7sYbE4w6aE3kCcyTU-LrP1pa5_ymDPAqioqZ1w> <https://secure.fredhutch.org/site/R?i=GEghbc4aYQIRwyh9476gEig83Z-Hjk71lr-g1zWvNpSkkNFf5OyA2Q> <https://secure.fredhutch.org/images/content/pagebuilder/fhcc-eml-hdr-shadow.png> <https://secure.fredhutch.org/images/content/pagebuilder/hdr-eml-hutch-news-fhcc.jpg> March 27, 2024 ⋅ A monthly digest of the latest from Fred Hutch Obesity, alcohol consumption ‘strongly correlated’ with colorectal cancers in adults under 50 <https://secure.fredhutch.org/site/R?i=bA_0F8UNqkP2H2Fv2wgIQEoY1qvE3V75ujqjY919oYUjKzrekfoQ4w> An international team of researchers co-led by Fred Hutch Cancer Center’s genetic epidemiologist Ulrike (Riki) Peters, PhD, has pinpointed what’s likely driving many colorectal cancers in people under age 50. Over the past two decades, multiple studies show that colorectal cancers have increased in young adults, often in sharp contrast to rapid declines of the disease in older adults. So far, no clear answers have emerged as to what’s behind this concerning rise. But a study published in the Annals of Oncology co-led by Peters and two international collaborators provides valuable insights into what’s likely driving cancers in people who are often too young to qualify for preventive screening. While the team found unique genetic risk factors, Peters said, they don’t explain the rise of colorectal cases in people under 50. Instead, the findings point to alcohol consumption and obesity as two important, but modifiable, risk factors. ________________________________ Answers from our cancer experts <https://secure.fredhutch.org/site/R?i=R2-C8SzYCJnHoQ_W1PZcNiMxm96nP_-qLG9fzEopYEhFpt9fBehLbw> Lymphedema is a common side effect of cancer treatment, particularly breast cancer surgeries that remove axillary (underarm) lymph nodes. Thanks to the passage of the 2022 Lymphedema Treatment Act, compression garments are now covered by insurance. Surgeries for the condition, however, often are not, according to our expert <https://secure.fredhutch.org/site/R?i=Ie0lb5cLqE5e8iNn u4PtSMhY4O5JUMgrOhIatU3CSnyEKFEUU3bz_w> . ________________________________ The Latest Blood test detects colorectal cancer <https://secure.fredhutch.org/site/R?i=vJhcvuCTyrYmY6zIi1Bo72mVpHbdwcTkSnWRh7wonK-BIBBuubEoyQ> A blood test intended for screening for colorectal cancer in people who are of average risk and not experiencing symptoms correctly detected colorectal cancer in 83% of people confirmed to have the disease, according to a study that included Fred Hutch researchers. Bacteria subtype linked to human colorectal cancers <https://secure.fredhutch.org/site/R?i=1yC6XAke-7zckC1XcZy11fBU5Hre_ljUGxdfTwQ6xYJM8Y3dUnMv1g> A study led by a Fred Hutch team of researchers suggests that a subtype of Fusobacterium nucleatum underlies colorectal cancer growth in humans. The findings could be useful in advancing new screening and treatments. Glial cells are more than our brain’s ‘glue’ <https://secure.fredhutch.org/site/R?i=FQx-5nUs-KxJVqaK25MJoATX9cSpo78YMdG_3bbVOeDPPvAMXQTpSA> Neuroscientist Aakanksha Singhvi, PhD, is at the forefront of a scientific reassessment of glial cells’ importance. Her team at Fred Hutch recently revealed how an individual glial cell independently regulates different neurons and helps integrate sensory information flowing through separate neural circuits. Immunotherapy cocktail tackles kidney cancer <https://secure.fredhutch.org/site/R?i=UmwEXOgz6GFQFcDJ2HQFiaq3DJZYcO8ZxtT8DZancy99D_hJgG9lsg> The treatment that Suzzanne Lacey received after a diagnosis of stage 4 kidney cancer was intended to help her immune system recognize that the multiplying cancer cells were abnormal, shrinking her tumor enough so it could be surgically removed. Grant supports multi-disciplinary discovery platform <https://secure.fredhutch.org/site/R?i=KAq2aMWjUBDPIztcQieplFlDwNdAtcd2ezpvgeYuZMyZ7Y60Vm1hfQ> A new $5.4 million grant from the National Cancer Institute will support the development of leading-edge functional genomics approaches to uncover new cancer therapy targets in tumor tissues donated by patients. Fred Hutch’s Christopher Kemp, PhD, and his team developed a method to grow tumor cells in tumor-like 3D structures called organoids, which better capture tumor behavior and enable them to uncover promising new vulnerabilities. ________________________________ Good News New chief nursing officer named <https://secure.fredhutch.org/site/R?i=cYNkFdI23M0_UOgPST4cg38JqH1dc3IWnvzO0snMIbp-fd_FxAXhcg> Denene Prophet-Williams, MBA, MLA, was named vice president and chief nursing officer at Fred Hutch. She is an accomplished health care executive with a 30-year nursing career, characterized by her exemplary leadership and strategic vision in academic, Magnet-designated and community hospitals. Dr. Toshio Tsukiyama elected to American Academy of Microbiology <https://secure.fredhutch.org/site/R?i=h9-M6AdrRXGIRWsvwfbW88QFt_hlmgQL37awmYS8baL7dDeVaJAK3Q> DNA-packaging expert Toshio Tsukiyama, PhD, DVM, was elected to the American Academy of Microbiology class of 2024, recognizing his scientific achievement and original contributions to advancing microbiology. ________________________________ Double Your Impact! Your generosity accelerates life-changing discoveries that will impact people facing cancer and related diseases. Give by March 31 and your gift will be matched up to $600,000. <https://secure.fredhutch.org/site/R?i=D7zAiPXYnYTlzGScoD_BvERulW4DajI2jUq6D5T3MP0KhUE5xwDkSQ> ________________________________ Share this newsletter with family or friends <https://secure.fredhutch.org/site/R?i=KSXJS-rjlruU2snUSabo7zAeYZSZSjO-H-8NZx2cK1UaQ4_s0DpJwg> <https://secure.fredhutch.org/site/R?i=y-eVQn9KWBV-KhgbMbkN-vEHHKSuL8W-BqNS56L2Enh-s9VfP4yGLA> 1100 Fairview Ave. N., Seattle, WA 98109 communications@fredhutch.org <mailto:communications@fredhutch.org> 206.667.5000 <https://secure.fredhutch.org/site/R?i=NTI-d144KqUq6AcMZOEak5SP1c1413w3ktaIV-nqb1VtJ_KiakAdvA> <https://secure.fredhutch.org/site/R?i=aygBxTiKquq8MMB9nDgd2aL3ZclGaL5TD-KG2kCAAY4hpZpCfexBKg> <https://secure.fredhutch.org/site/R?i=q7mACgB_N3vzMY-2Jw4nUsvzDYnJIE_ZK_5iPNhp7tr3MZ7h3n9L8A> <https://secure.fredhutch.org/site/R?i=CNlX9bxnGHUNEwRC6YyjhGKqr2AOMe612OxgZDxP_R6vmebFD3PupA> ________________________________ Fred Hutchinson Cancer Center is a 501(c)(3) nonprofit organization. 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All rights reserved. <http://engage.fredhutch.org/site/PixelServer?j=ugsFtKYrkgWc1qf2-8YIWe6SLWiugYG8zKjL4DmWeNI1nW50s6fp_w> h.org/site/R?i=UmwEXOgz6GFQFcDJ2HQFiaq3DJZYcO8ZxtT8DZancy99D_hJgG9lsg", "url/anchorText": "Immunotherapy cocktail tackles kidney cancer", "url/prefixText": "helps integrate sensory information flowing through separate neural circuits", "url/suffixText": "The treatment that Suzzanne Lacey received", "url/urlTextSpan": { "@type": "TextSpan", "beginIndex": 3017, "length": 44 }, "@EntityId": "e088be16-920c-4c27-9d7b-954176700515", "@correlationTrail": "AssetId=286baa03-8e7c-4652-baee-f78665118664;ExtractionId=513f5a5b-d414-4054-82d1-4cad4ec79517;EntityId=e088be16-920c-4c27-9d7b-954176700515", "@extractionTimeUtc": "2024-03-27T18:01:16.8473027Z" }, { "@type": "ContactPoint", "@context": "http://schema.org", "@source": "TEE,52.0.0,20240312.12,3791e05346c4a5b21b341bcee17a279711f6280d;en-US.ContextUrl,52.0.0,2021.5.5.1,2021.5.5.1", "@entityExtractionTrustLevel": 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