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HomeMy WebLinkAbout062624 - Revealing the biology behind drug's success in a rare liver cancerALERT: BE CAUTIOUS This email originated outside the organization. Do not open attachments or click on links if you are not expecting them. Solving a molecular puzzle | Skin cancer prevention | DEI commitment continues ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ View as Web page <https://secure.fredhutch.org/site/R?i=O3mZdu0nh1qITA6uFJbu83x7E_Z61rVSeZgCJrImTDnVkWZe-ICW_Q> <https://secure.fredhutch.org/site/R?i=fATO9WLExVmo1HkxzdODrGeB-p7jQAt9tLiG382dIcUtY_q2fR1juQ> <https://secure.fredhutch.org/images/content/pagebuilder/fhcc-eml-hdr-shadow.png> <https://secure.fredhutch.org/images/content/pagebuilder/hdr-eml-hutch-news-fhcc.jpg> June 26, 2024 ⋅ A monthly digest of the latest from Fred Hutch Mapping a pathway to hope <https://secure.fredhutch.org/site/R?i=-bK_yQoJxHhAop3ANpBzmEUO8nHlW5Rt5TqrcZ9p171Cdt02yn1k1g> Sometimes it takes a little magic to solve a molecular puzzle. Not so much magic as MAGI1, a nondescript scaffolding molecule that turns out to play a big role in explaining why a certain drug works in a rare liver cancer, and how it could work better, according to a new study from the Kugel Lab at Fred Hutch Cancer Center. Researchers discovered that MAGI1 is key to understanding how to exploit a vulnerability in a mutated form of an under-researched liver cancer. The study, by liver and pancreatic cancer researcher Sita Kugel, PhD, and lead co-authors Iris Luk, PhD, and Caroline Bridgwater, was published in May. Much of the work described in the study was initiated at Fred Hutch by Kugel’s late husband, Supriya “Shoop” Saha, MD, PhD, who died of complications from a bone marrow transplant in 2020 at the age of 40. Kugel continued and completed the work after his death. Saha had discovered that the disease, intrahepatic cholangiocarcinoma, or ICC, has become more common over the last 40 years but doctors have few options to treat it. Saha found that a genetic mutation occurring in up to 37% of patients causes their tumors to grow differently than ICC tumors without the mutation. Somehow this difference makes those mutant cells vulnerable to a drug called dasatinib, a weakness in the cancer’s defenses that could lead to a new therapy. Read the full story. <https://secure.fredhutch.org/site/R?i=kUS4_LmspJq8kp_1Q7OMMuXhW50to pjZNj1nsutBoia64G1zjmhhug> ________________________________ DEI commitment continues <https://secure.fredhutch.org/site/R?i=Cej9ijvgdEZDPS-8wwW6eQ0m1_0ApTey9TShBXHs4inB6vtS1J3Odw> Dr. Shaun Harper gives the keynote address during the Fred Hutch Diversity, Equity & Inclusion Summit. Photo by Robert Hood / Fred Hutch News Service With diversity, equity and inclusion efforts under siege at many institutions, Fred Hutch stands out for its early, authentic, substantial and enduring commitment — and should say so loudly. That was the call to action at the 2024 Fred Hutch Diversity, Equity & Inclusion Summit — Aligning our Actions for Critical Change <https://secure.fredhutch.org/site/R?i=OXDejxWdvdjFEHM87xu9 8TpDH9YT6rm5TCjcNOmLK393YoxpAbnvmw> — held June 6. ________________________________ The Latest What's your skin strategy? <https://secure.fredhutch.org/site/R?i=54LuMAmQNPcWJTNyI0JTLi4NibtLdsIutJuOZmnhJXzu0LK7GxUakA> Summer is here and the sun is out so we’ve gathered the latest information on skin cancer prevention and research from experts at Fred Hutch. How do you build partnerships for health equity? <https://secure.fredhutch.org/site/R?i=m7lCdwOFmFZ-MvP6Xrix_yRoi3Ovw8p1UvxAXbJ8iJGAt2ZqfEIlLA> Health equity experts from Fred Hutch and beyond shared practical tips for creating lasting partnerships between community members and the scientists striving to improve their health at the annual Pathways to Equity Symposium, held June 6. How cancer centers plan to enhance diversity <https://secure.fredhutch.org/site/R?i=m6vaZMn6ISbWl7FwUg4Sb2epzkow-r5OCzpCh13PPhedQwdMZLTouQ> Cancer patients need care, but they also need to feel represented. Patients need to see themselves in the clinicians and nurses; the radiation technicians, the scientists who investigate their therapies and the leaders who guide them. Taking a frothy risk to advance gene therapy <https://secure.fredhutch.org/site/R?i=Y3Gabfco_dtemyxhIUGS-7WTH_59oIjIutuTnIZXFRoLjQ1t3iUeYQ> Scientists hope foam could be a cost-reducing, access-enhancing vehicle for delivering future gene therapies. Fred Hutch’s Matthias Stephan, MD, PhD, works to make today’s leading-edge cancer therapies more easily available. Oncology review course marks 15 years <https://secure.fredhutch.org/site/R?i=HuDoffvU5kk7dfUhwiwyqYtz7A2m-pnW2XkaCJ0xONRuuAESqVTqag> Andrew L. Coveler, MD, created the Comprehensive Hematology & Oncology Review Course in 2009, to get ready for his board exams. Fifteen years later, it’s still going strong. ________________________________ Science Links What doesn’t kill you makes you stronger: <https://secure.fredhutch.org/site/R?i=nGmmyGYAaFs-kBXZ6vt6oMRWtf-WvLkjomvyRe93Kcu-ZkFKv4SlPg> Bacteria that withstand fungal ‘bully’ gain resistance to last-resort antibiotic. Secret to tamping down GVHD may lie in microbial genetics: <https://secure.fredhutch.org/site/R?i=z9OfYYRjUemkgCwwrJa6k2Zg4JWR3isbqc5JPY2Nx957OLxnGIYGiA> Bone marrow transplant study shows donor immune cells that target recipient microbiome can influence GVHD severity. ________________________________ Good News Bladder cancer patient manages the stress of disease <https://secure.fredhutch.org/site/R?i=cCqWm35jW_txEQzBW7MY0Ykc2c5y3tA7FFc8FNA9Df4rVRpIdnia_w> Bladder cancer is the sixth most commonly diagnosed cancer, although it’s four times more common in men. That makes Carlette Winfrey’s story unique. Tackling an aggressive form of pancreatic cancer <https://secure.fredhutch.org/site/R?i=zQ1Fl9vZTMLBkyp8DLPT69R5NqWvGmrE6Vf8m87IkQrRgF6NKQNVfg> Fred Hutch postdoctoral fellow Stephanie Dobersch, PhD, received an American Cancer Society Fellowship to study a highly lethal form of pancreatic cancer, known as basal pancreatic ductal adenocarcinoma (PDA). ________________________________ Register for Obliteride Today! Fred Hutch Obliteride’s bike ride and 5K walk/run empowers people to help cure cancer faster by raising funds for Fred Hutch. 5K walk/run registration closes July 25. <https://secure.fredhutch.org/site/R?i=427AyHM4bjKcWqYW69OftVKb17jOKAybdITZayS0lafsUDHhxTzKeg> ________________________________ Share this newsletter with family or friends <https://secure.fredhutch.org/site/R?i=wA5gYyMlpYa1dQi_d20gFTcEDmOKuqG8ruTF1OeweSdZb0yNiY0rJg> <https://secure.fredhutch.org/site/R?i=mAJ2IVfudD3ZbQ8JL_LrJ1ZTVm7POqNLHo0465c5pMuzjRbL2fk4DA> 1100 Fairview Ave. N., Seattle, WA 98109 communications@fredhutch.org <mailto:communications@fredhutch.org> 206.667.5000 <https://secure.fredhutch.org/site/R?i=X7wXs6iWZzCwSRXMhk_qh31TOHfq5NlagyjuyylxIzeNojuKV6lM9g> <https://secure.fredhutch.org/site/R?i=uXQSILZWGfu7zihC2fCwMUSZ3ilZ4Zh_me9eOmD1IYqXNrx0ZKczWg> <https://secure.fredhutch.org/site/R?i=xFUO6YroOMg8dLqIRwvBLWj9nmQMchEOFZqtRSLKETEp4tliCC9R0w> <https://secure.fredhutch.org/site/R?i=dqxSflcsOhr9pzWfn1sDDBDsP05zq7Af-1xygH72N1VHOuowDcwmZw> ________________________________ Fred Hutchinson Cancer Center is a 501(c)(3) nonprofit organization. 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