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HomeMy WebLinkAbout082824 - A quarter century of lifesaving discoveries in prostate cancerALERT: BE CAUTIOUS This email originated outside the organization. Do not open attachments or click on links if you are not expecting them. Prostate Cancer SPORE | BRCA1/2: screening for men | Immunotherapy transforms oncology ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ View as Web page <https://secure.fredhutch.org/site/R?i=NkfeDBsV2TRaKhWwZOHIoTenN7fN1GeCRCqbcApGBXlPkv3_mGotsg> <https://secure.fredhutch.org/site/R?i=h8qO1XGpZTn2RurQ3aeiUVMzHHF1uYssVkFSO6ZVJZ4b-t1bZYNjog> <https://secure.fredhutch.org/images/content/pagebuilder/fhcc-eml-hdr-shadow.png> <https://secure.fredhutch.org/images/content/pagebuilder/hdr-eml-hutch-news-fhcc.jpg> August 28, 2024 ⋅ A monthly digest of the latest from Fred Hutch Pacific Northwest Prostate Cancer SPORE insights have transformed patient care and understanding of prostate cancer biology <https://secure.fredhutch.org/site/R?i=OPMDERcGszfmnp83Z-FPvWyG-ZRJNIlp1mrS 0wen4EmYl_VSlYouOQ> Today, a patient diagnosed with advanced prostate cancer has options. Doctors can offer a suite of androgen-suppressing drugs to extend their life. There are genetic tests that can show whether they are a candidate for more-targeted treatments. These tests can also reveal whether their family members are at higher risk for prostate and other types of cancer. This was not always the case. And many of these breakthroughs have been made possible by 25 years of transformative prostate research performed by scientists in the Pacific Northwest Prostate Cancer Specialized Program of Research Excellence. The National Cancer Institute created the SPORE program to strengthen ties between bench and bedside and hasten the flow of breakthroughs and insights between them. “Twenty-five years of continued funding is a testament to the consistently excellent science conducted by PNW Prostate Cancer SPORE researchers,” said Fred Hutch Cancer Center prostate cancer expert Peter Nelson, MD, who heads the PNW Prostate Cancer SPORE. “Our scientists have made practice-changing breakthroughs and widened the scope of treatment and screening options available to prostate cancer patients.” Headquartered at Fred Hutch, the PNW Prostate Cancer SPORE brings together forward-thinking prostate cancer researchers at Fred Hutch, the University of Washington, Oregon Health & Science University and the University of British Columbia. In late 2023, the international team garnered a fifth renewal, guaranteeing 30 years of continuous funding for innovative prostate cancer research. Read the story <https://secure.fredhutch.org/site/R?i=oN4V9OgC53NAoNI03YFujTUOHtC52EGyYeMmFTSap2Iy6L6t-KpPoA> . ________________________________ Obliteride community brings unstoppable energy <https://secure.fredhutch.org/site/R?i=d9CK2KpTkwQTto8_Mm1tLCNwwVL2FaCuEAU6ZlstATMBZsjO58-0uw> Photo by Robert Hood / Fred Hutch News Service This year marked the 12th annual Obliteride <https://secure.fredhutch.org/site/R?i=fngws5bi6PHp_mK2BCbbESBr9AWmxqf3AeDx3nHVgGPPhYevVVgftw> — a bike ride and 5K walk/run that connects and empowers people to help cure cancer faster by raising funds for Fred Hutch. With more than 6,200 people registered, and more than 800 volunteers, this year’s event was the largest ever. In addition to individuals, nearly 500 teams participated, including 100 corporate teams from around the region. ________________________________ The Latest BRCA1/2: Why men should be screened <https://secure.fredhutch.org/site/R?i=IKwZEHV57wy_F4bM4E4U7S-tMLi7K_e9YSd-eoMy8UXqkNM_1ZfuTA> New research shows that men can carry mutations in the BRCA1 and BRCA2 genes that increase their risk of several cancers, but new national guidelines are helping to educate patients. Finding a rare bile duct cancer’s weakness <https://secure.fredhutch.org/site/R?i=EFasTpuQTBjKBwBkv3WOihja4HxaYEKszY9iQOJOiyeAmHX6ca3BoQ> Fred Hutch postdoctoral fellow Liberalis (Debraj) Boila, PhD, has received two awards from the Department of Defense Rare Cancers Research Program and the Cholangiocarcinoma Foundation to support his studies of an aggressive bile duct cancer called intrahepatic cholangiocarcinoma, or ICC. How immunotherapy has transformed oncology <https://secure.fredhutch.org/site/R?i=ckkx8OAFIaXnj67Qb9IWxS4F6EJJLy9pLthbf1lmH-DMV7zn_ggzKg> Fred Hutch Immunotherapy Director Lawrence Fong, MD, talks about how the field has transformed oncology. In an interview, he outlines the specific initiatives designed to accelerate advances including the just announced Catalyst Grant Program. ‘Black hole’ formed by aging cells hobbles thymus <https://secure.fredhutch.org/site/R?i=dRzDt_Bar_GIUrEBQMpo2lK8NDBCbUlFLaHo_mSt27A6cN4AmJ8jjg> A collaborative research project led by Fred Hutch thymus and regenerative medicine expert Jarrod Dudakov, PhD, revealed non-functional cells that accumulate in the thymus, a key immune organ. The “black hole” of cells limits the function and regeneration of the thymus. EGFR discovery 20 years ago rocked lung cancer research <https://secure.fredhutch.org/site/R?i=8OJrgehyTc4wLGQ6YUx0BbQhp6iI-AYz3pOi22JYSIKuP8s2R0onxw> In 2004, Fred Hutch President and Director Thomas J. Lynch Jr., MD, was lead author on an academic paper deciphering the role that a mutation in the EGFR gene plays in the treatment of lung cancer. Read one Fred Hutch patient’s story of how she has benefited from that discovery since 2006. Curiosity, connection and C. elegans <https://secure.fredhutch.org/site/R?i=Fbm6n8mIAOyHtHClgU4v-JcyHe6VRdoNoTGRj8UOD69-sLnendBq1g> The long path from curiosity to cure in disease research often branches in many unpredictable directions. The path that led molecular biologist Nicolas Lehrbach, PhD, to publication in PLOS Biology of a genetic study that sheds light on an extremely rare genetic disorder took an unexpected turn about a decade ago. ________________________________ Good News From postdoc to principal investigator <https://secure.fredhutch.org/site/R?i=l9I50zctUX15O--YXKGjmeRbjiOznapzuj1U7IA6juJP-t5auIqv1Q> Phoebe Hsieh, PhD, a postdoctoral research fellow at Fred Hutch, recently received the Postdoc-to-Faculty Transition Award from the Cystic Fibrosis Foundation. The award, which helps young scientists start an independent cystic fibrosis research program, includes salary support and research funding in the final two years. Parkhurst named 2024 ASCB fellow <https://secure.fredhutch.org/site/R?i=LGNlcxLHFRYplmmV2SfVmt5R7H-QVlj2frrOBYT5QbuwVeP8J3-5dQ> The American Society for Cell Biology named Fred Hutch cell biologist Susan Parkhurst, PhD, a fellow. The honor acknowledges scientists chosen by their peers for lifetime achievements in the field of cell biology. ________________________________ August is Make-A-Will Month! With the help of our trusted partner, FreeWill, you can create your will in just 20 minutes and protect the people and causes you love. By including Fred Hutch, you’ll create a legacy of turning discoveries into cures for generations to come. <https://secure.fredhutch.org/site/R?i=8iCrOlKHDLngBrHW5Yv06lcuMnNZ2KMKr0zjYsPhtOfTstPnpOXifA> ________________________________ Share this newsletter with family or friends <https://secure.fredhutch.org/site/R?i=IGKHU8VWy3FWMdpC9qooLYd5tAuGuNhghGaJhjlfqrp3smj2siTHrw> <https://secure.fredhutch.org/site/R?i=IjuPqfpA42CndqixPXsSlqqLg2tUDRixzCYL0mtr2NzEgbHSTuOKfQ> 1100 Fairview Ave. N., Seattle, WA 98109 communications@fredhutch.org <mailto:communications@fredhutch.org> 206.667.5000 <https://secure.fredhutch.org/site/R?i=igmcUiqxYz1YaFiuUoyPPe_QULnTmLtS6Sn0TTXmI1YxsXlx7hZWsw> <https://secure.fredhutch.org/site/R?i=C3vq73DzqgqjO97AUgPT-TZHyUZ85ggShq_CGTQWlb6Jo4Lx__8Vkg> <https://secure.fredhutch.org/site/R?i=JW-0WQdBsNvj0Scl3gVcFbSTHAMx3HEV9m8m5CugfhDbe-tkQAgbKw> <https://secure.fredhutch.org/site/R?i=5N28w1ZZneNwoDR2ZoDcVuGY77DBE048ieFqYRVA_2FJSDQLiwIAYA> ________________________________ Fred Hutchinson Cancer Center is a 501(c)(3) nonprofit organization. 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